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Viagra, Sildenafil citrate

sildenafil citrate

CAS: 171599-83-0

Molecular Formula: C28H38N6O11S

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Viagra, Sildenafil citrate - Names and Identifiers

Name sildenafil citrate
Synonyms Viagra
Sidenafil citrate
sildenafil citrate
Viagra, Sildenafil citrate
Sildenafil Citrate (100 mg)
Sildenafil citrate, Professional supply
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-3-propyl-2,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt
5-[2-Ethoxy-5-(4-methylpiperazin-1-yl-sulphonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazol[4,3d]pyrimidin-7-one citrate
5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl)sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo[4,3-d]pyrimidin-7-one citrate
1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt
1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine, 2-hydroxy-1,2,3-propanetricarboxylate
CAS 171599-83-0
EINECS 200-659-6
InChI InChI=1/C21H28N6O4S/c1-4-6-16-18-19(25-24-16)21(28)23-20(22-18)15-13-14(7-8-17(15)31-5-2)32(29,30)27-11-9-26(3)10-12-27/h7-8,13H,4-6,9-12H2,1-3H3,(H,24,25)(H,22,23,28)
InChIKey DEIYFTQMQPDXOT-UHFFFAOYSA-N

Viagra, Sildenafil citrate - Physico-chemical Properties

Molecular FormulaC28H38N6O11S
Molar Mass666.7
Density1.447g/cm3
Melting Point187-189°C
Boling Point698.72°C at 760 mmHg
Flash Point376.372°C
Water Solubility3.488g/L(temperature not stated)
Solubility DMSO: >20mg/mL
Vapor Presure0mmHg at 25°C
Appearancewhite powder
ColorWhite
Merck14,8489
Storage Condition2-8°C
StabilityStore in Freezer
Refractive Index1.683
Physical and Chemical PropertiesAppearance: white crystalline powder
solubility: soluble in dimethylformamide
Melting Point: 190-193
In vitro studySildenafil citrate is a potent reversible selective inhibitor of PDE Ⅴ, which can effectively block the hydrolysis of cGMP (Ki ∼ 3 nM). Sildenafil exhibited high affinity for type PDE Ⅴ and Ⅵ with inhibition constants (Ki) of ∼ 3.5 and 33 nM, respectively. In the organ bath, Sildenafil enhanced the relaxation of precontracted corpus cavernosum smooth muscle induced by sodium nitropramizate or transmural electrical stimulation, suggesting that sildenafil enhanced NO-mediated diastolic activity. Sildenafil citrate increased intracellular cGMP concentrations in cultured sodium nitroprunate-treated smooth muscle cells and in rabbit corpus cavernosum in vitro. In the liver, Sildenafil is metabolized by cytochrome P450 and converted into an active metabolite with properties similar to the parent compound.
In vivo studyIn anesthetized dogs, Sildenafil citrate enhances penile erectile function under pelvic nerve stimulation by measuring intracavernous pressure. Sildenafil citrate significantly reversed the impaired Carbachol-stimulated relaxation and inhibited the formation of superoxide in the corpus cavernosum tissue of hypercholesterolemic rabbits. In Sprague-Dawley rats, Sildenafil improved erectile function in a time-dose-dependent manner, with maximal erectile recovery occurring on day 28 at a dose of 20 mg/kg daily. In Sprague-Dawley rats, the use of Sildenafil resulted in preservation of smooth muscle collagen ratio and preservation of CD31 and eNOS expression. In Sprague-Dawley rats, Sildenafil significantly reduced the apoptotic index and increased the phosphorylation of akt and eNOS compared to controls.

Viagra, Sildenafil citrate - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description36 - Wear suitable protective clothing.
WGK Germany3
RTECSTL4284390
HS Code2933595960
Viagra, Sildenafil citrate
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Shanghai Worldyang Chemical Co.,Ltd.
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Shanghai Worldyang Chemical Co.,Ltd.
Featured ProductsSpot supply
Product Name: sildenafil citrate Request for quotation
CAS: 171599-83-0
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: 13651600618
WhatsApp: +8613651600618
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: sildenafil citrate Request for quotation
CAS: 171599-83-0
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: sildenafil citrate Request for quotation
CAS: 171599-83-0
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Sildenafil citrate Visit Supplier Webpage Request for quotation
CAS: 171599-83-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: sildenafil citrate Request for quotation
CAS: 171599-83-0
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
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View History
Viagra, Sildenafil citrate
H-D-ALA(3,3-DIPHENYL)-OH
63553-68-4
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